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bd40bc7c7a However, thrombotic antiphospholipid syndrome is regarded as a major adverse prognostic factor in patients with lupus (53). Primarily, aCL are not as strong a risk factor for thrombosis as LA. APL account for a significant proportion of thromboses in the general population (55-57).The presence of additional prothrombotic risk factors in aPL- positive individuals likely influences thrombosis risk. 14th international congress on antiphospholipid antibodies task force report on obstetric antiphospholipid syndrome. J Rheumatol (2006) 33(11):2214–21. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. Table 1- Summary of the Sydney Consensus Statement on Investigational Classification Criteria for the APS (61).Essentially, the clinical criteria remained unchanged; however, two important modifications were made: the time elapsed between two positive determinations was extended to 12 weeks to assure the detection of persistent antibodies only; and anti- 2-glycoprotein 1, both IgG and IgM, were added to the laboratory criteria. The real prevalence – and association – of uterine malformations, infections, other autoimmune disorders (thyroiditis, celiac disease), and congenital thrombophilias with REM is not precisely known.
The definition of aPL positivity among studies was unequal and most did not follow international criteria recommendations (1). Initially, other identifiable triggers of REM, which can occur in up to 3% of all fertile women, must be ruled out. Lupus anticoagulant is consistently the most powerful predictor of thrombosis (49-51). Silver RM, Parker CB, Reddy UM, Goldenberg R, Coustan D, Dudley DJ, et al. As with fetal loss, controversial results have been yielded between low titers of aPL and REM, and a definite association is not possible. Some suggestions: Go back to the last page Go to the home page .. The protein has a fishhook shape and binds to anionic phospholipid bilayers through cationic and hydrophobic aminoacids in the fifth of its 5 SCR domains, near the carboxyterminus (19).